PYRAZOLYL INDOLYL DERIVATIVES AS PPAR ACTIVATORS Russian patent published in 2009 - IPC C07D403/12 A61K31/4155 A61P3/10 A61P9/00 

FIELD: medicine.

SUBSTANCE: invention refers to new compounds of formula: I where R¹ represents hydrogen or C_1-7-alkyl; R² and R³ independently represent hydrogen; R⁴ and R⁵ independently represent hydrogen; R⁶, R⁷, R⁸ and R⁹ independently represent hydrogen, C_1-7-alkyl; and one of R⁶, R⁷ and R⁸ represents where R¹⁰ represents hydrogen, C_1-7-alkyl; R¹¹ represents hydrogen, C_1-7-alkyl; one of R¹² or R¹³ represents hydrogen, C_1-7-alkyl or fluorine-C_1-7-alkyl; and the other represents undivided electron pair; R¹⁴ represents hydrogen, C_1-7-alkyl, halogen; R¹⁵ represents aryl or aryl substituted with 1-3 groups chosen from C_1-7-alkyl C_1-7-alkoxy, halogen, fluorine-C_1-7-alkyl and fluorine-C_1-7-alkoxy; and n has a value 1, 2 or 3; and to all their enantiomers and to pharmaceutically acceptable salts and/or esters. The invention also concerns the pharmaceutical compositions.

EFFECT: production of new biologically active compounds with agonist activity with respect to PPARδ and PPARα.

20 cl, 25 ex, 1 tbl