TRI-INDOLYLMETHANE DERIVATIVES SUBSTITUTED IN INDOLE NUCLEUS, METHOD OF OBTAINING SAID COMPOUNDS AND ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY THEREOF Russian patent published in 2010 - IPC C07D209/04 C07D403/14 A61K31/4025 A61P31/04 A01N3/00 A01N1/00 A61L2/16 

FIELD: chemistry.

SUBSTANCE: invention relates to the novel tri-indolylmethane derivatives of general formulae I and II. The compounds can be used during bacterial or fungal infection and for protecting different products from harmful effect of bacteria or fungi, particulary as antiseptics or for disinfection. In general formulae

I

or II , where R₁; R₇; R₁₃ independently represent hydrogen, alkyl, substituted alkyl, R₂; R₈; R₁₄ independently represent hydrogen, alkyl, substituted alkyl, -OH, -OR, C₁-C₄acyl, where R is alkyl or substituted alkyl, R₃-R₆; R₉-R₁₂; R₁₅-R₁₈ independently represent hydrogen, alkyl, substituted alkyl, -OH, -OR, C₁-C₄acyl, where R represents alkyl or substituted alkyl, Y is an anion of a pharmacologically acceptable organic or inorganic acid; R₁₉ is hydrogen, alkyl, substituted alkyl acyl, metal ion. The invention also relates to methods of obtaining compounds of formulae I and II, a pharmaceutical composition and use. The invention relates to a method for synthesis of tri-indolylmethane of formula III mono-substituted in the methane group which is an intermediate compound.

EFFECT: obtaining tri-indolylmethanes of general formulae I or II having antibacterial and antifungal activity.

17 cl, 4 dwg, 4 tbl, 5 ex