CYTOTOXIC LINEAR HETEROCYCLIC DERIVATIVES OF ANTHRACENEDIONE HAVING IN SIDE CHAIN CYCLIC DIAMINES, ACTIVE TOWARDS TUMOUR CELLS WITH MULTIDRUG RESISTANCE Russian patent published in 2011 - IPC C07D209/56 A61K31/343 A61P35/02 C07D307/77 A61K31/403 A61P35/00 C07D333/50 A61K31/381 

FIELD: chemistry.

SUBSTANCE: invention relates to anthracenedione derivatives which are suitable for therapy of oncological diseases, having the formula:

, where W is a fragment of a five-member heterocycle containing one or two heteroatoms selected from N, O or S, optionally substituted with alkyl, halogen; Y is a monocyclic diamine residue containing an exocyclic amine group, or a polycyclic diamine with bridging amine groups, which is a compound in which two amine groups are involved in formation of 4- or 6-member ring systems containing 2-6 carbon atoms and bonded by one, two or three bridging atoms, where Y is optionally substituted with one or more substitutes selected from alkyl, halogenalkyl, halogen, hydroxyl, hydroxyalkyl, carbamoyl and CO₂R, where R denotes alkyl; X denotes alkylene, CO or SO₂; n and m are independently range from 0 to 2; Z¹ is selected from hydroxy, alkoxy -NH₂, -NHR¹, -NR¹R², where R¹ and R² denote alkyl, aminoalkylamino, halogen; Z² is selected from hydroxy, alkoxy, fluorine.

EFFECT: obtaining novel anti-tumour compounds.

1 cl, 18 ex, 3 tbl