FIELD: chemistry.
SUBSTANCE: invention refers to compounds of the formula (I): 
, where R1 is C1-C8alkyl optionally substituted with one to three substitutes selected out of substitute group A; R2 is C1-C6alkyl or C1-C6alkoxyC1-C6alkyl; R3 is C1-C6alkyl or C1-C6alkoxy; or R2 and R3 together with adjoining carbon atoms form optionally substituted non-aromatic 5-10-member carbon ring; R4 is hydrogen; G is group represented by the formula: 
or 
the rest as provided in the invention claim; and to pharmaceutical composition, application of claimed compounds, and method of atopic dermatitis prevention or treatment.
EFFECT: novel compounds useful as atopic dermatitis treatment medication and antipruritic medicines.
24 cl, 75 ex, 290 tbl
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