MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS Russian patent published in 2015 - IPC C07D401/12 C07D215/56 C07D417/12 C07D405/12 C07D409/12 C07D413/12 C07C215/76 C07D209/08 C07D209/12 C07D209/14 C07D209/18 A61K31/47 A61K31/4709 A61P25/00 A61P31/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula A-I, where G₁ stands for hydrogen atom or R'; G₂ stands for halogen atom, CN, CF₃, isopropyl or phenyl, where said isopropyl or phenyl is optionally substituted with up to three substituents, independently selected from WR^W; G₃ stands for isopropyl or (C₃-C₁₀)cycloaliphatic ring, where said G₃ is optionally substituted with up to three substituents, independently selected from WR^W; W stands for bond or (C₁-C₆)alkylidene chain, where up to two methylene groups of W residue are optionally and independently substituted for -CO₂- or -O-; R^W stands for R'; and R' is independently selected from hydrogen atom or (C₁-C₈)alkyl group. Invention also relates to method of obtaining compound of formula FF (stands for bromine atom, fluorine atom or tret-butyl; G₃ stands for tret-butyl) by hydrogenation of respective nitrocompound in presence of palladium catalyst and to methods of obtaining C-9 and 433 compounds, which include stage of hydrogenation of respective nitrocompound in presence of palladium catalyst as intermediate stage.

EFFECT: formula A-I compounds, which are intermediate for synthesis of modulators of ATP-binding cassette ("ABC") transporters.

35 cl, 4 tbl, 80 ex