NOVEL ANTIOGENESIS INHIBITING COMPOUNDS AND USE THEREOF Russian patent published in 2010 - IPC C07D401/12 C07D405/14 A61K31/4439 A61P27/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) , where D is pyrrolidine, X is a radical selected from a group containing C=O, SO₂, (C=O)-NH, CH₂, O-(C=O), (C=O)-O, (C=S)-NH, Y is a radical selected from a group containing - (CH₂)_n-E-(CH₂)_m-L-(CH₂)_k, where E is O, k, m and n are separately and independently equal to 0, 1, 2 and 3, Z is an alkyl, where the alkyl is CH₂ or CH₂CH₂, A is a radical selected from a group containing benzyl, substituted benzyl, phenyl, substituted phenyl, alkyl and substituted alkyl, cycloalkyl, heterocyclyl, aryl, alkyloxyalkyl, substituted alkyloxyalkyl, alkyloxyaryl, B is a radical of formula (II) , where R₁ is selected from a group containing H, alkyl and substituted alkyl, cycloalkyl, R₂ is selected from a group containing H, benzyl, substituted benzyl, phenyl, substituted phenyl, alkyl and substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, heteroaryl, cycloalkylalkyl, substituted cycloalkylalkyl, G is an amino group which is substituted by a heteroaryl or substituted heteroaryl, and where Q and L each independently denotes a radical selected from a group containing (C=O)-NH, NH, CH₂, NH-(C=O)-NH, NH-(C=O), NH-SO₂, NR^c, (C=O)-NR^c, and where R^a, R^b, R^c and R^d each independently denotes a radical selected from a group containing H, alkyl, cycloalkyl, heterocyclyl, aryl, substituted aryl, as well as to use of these compounds as integrin inhibitor and for making a medicinal and a diagnostic agent, to a pharmaceutical composition based on these compounds and to methods of treating integrin-associated condition.

EFFECT: novel compounds which are integrin inhibitors and can be used to treat diseases where angiogenesis inhibition is necessary are obtained and described.