METHOD OF POSTMEDICAMENTOUS IMMUNODEFICIENCY ASSESSMENT Russian patent published in 2010 - IPC G01N33/53 G01N33/48 

Abstract RU 2393480 C2

FIELD: medicine.

SUBSTANCE: there is offered a method of postmedicamentous immunodeficiency assessment by single intraperitoneal introduction to experimental rats of an injection of 0.5 ml of a cytostatic agent - Cyclophosphan in dosage 4 mg/100 g of body weight; two months later there are evaluated weights of spleen (WS) and thymus (WT), leukocyte (LK) and blood lymphocyte (LP), blast-transformation reaction (BTR), spleen antibody-forming cells (AFC), leukocyte phagocytic activity (LPA) and phagocytic index (LPI). The method is characterised by the fact that an immune activity index (IAI) is calculated by formula , and if the IAI is less than 580 units, development of prolonged postmedicamentous immunodeficiency is stated.

EFFECT: method improvement.

6 ex, 1 tbl

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Authors

Grinzajd Jurij Moiseevich

Demeshko Natalija Ivanovna

Pigunova Ljudmila Aleksandrovna

Mel'Nikova Valentina Ivanovna

Skvortsova Zhanna Aleksandrovna

Kartazaeva Vera Aleksandrovna

Dates

2010-06-27Published

2008-08-07Filed