FIELD: medicine.
SUBSTANCE: there is offered a method of immunosuppression of immune cells by processing in vitro with mixed nonmetabolised cyclophosphamide and its active metabolites in the ratio 1000:0.75-1000:3. The degree of immunosuppression of the processed cells authentically increases in 1.4-2.2 times. The method is based on a first described property of nonmetabolised cyclophosphamide to intensify the immunodepressive effect of active metabolites. The method has been supported in experiences with using a system of adoptive syngeneic transfer of immune cells and in murine spleen T-lymphocyte proliferation experiments.
EFFECT: method can be used in processing of bone marrow cells before autotransplantation in treating leukosis, extracorporal pharmacotherapy and local chemotherapy of cancer.
3 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| AGENT INHIBITING LYMPHOCYTE PROLIFERATION | 2000 |
|
RU2179170C1 |
| METHOD OF ,PARTICULARLY, IMMUNOSUPPRESSIVE ACTION OF XENOBIOTICS | 0 |
|
SU1587446A1 |
| METHOD FOR REDUCING ALCOHOLIC MOTIVATION IN MICE | 2020 |
|
RU2744411C1 |
| IMMUNOMODULATING AGENT | 1993 |
|
RU2108100C1 |
| IMMUNOMODULATOR | 2018 |
|
RU2691143C1 |
| METHOD FOR STIMULATING NEUROGENESIS IN THE HIPPOCAMPUS | 2017 |
|
RU2675111C2 |
| AGENT "LIZOLAKT" POTENTIATING ANTITUMOR ACTIVITY OF CYTOTOXIC PREPARATIONS | 2006 |
|
RU2311196C1 |
| MUCOSAL INDUCTION OF ANTIGEN TOLERANCE | 2006 |
|
RU2420569C2 |
| IMMUNOMODULATOR | 2019 |
|
RU2702114C1 |
| DEVICES AND METHODS FOR SELECTION OF CELLS RESISTANT TO APOPTOTIC SIGNALS AND THEIR APPLICATIONS | 2013 |
|
RU2630301C2 |
