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2 744 411

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IPC

A61P25/32(2006-01-01)

A61P37/02(2006-01-01)

A61K31/17(2006-01-01)

A61K31/515(2006-01-01)

(21) (22)

Application

2020112546, 2020-03-25

(24)

Start date

2020-03-25

(22)

Actual filing date

2020-03-25

(45)

Published

2021-03-09

(72)

Inventor

Markova Evgeniya ValerevnaSavkin Ivan Vladimirovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Institut Fundamentalnoj I Klinicheskoj Immunologii"

METHOD FOR REDUCING ALCOHOLIC MOTIVATION IN MICE Russian patent published in 2021 - IPC A61P25/32 A61P37/02 A61K31/17 A61K31/515

Abstract RU 2744411 C1

FIELD: medicine.

SUBSTANCE: method for reducing alcohol motivation in mice is proposed, including the collection of splenocytes from alcoholized mice, their incubation in vitro for 10-25 min with an immunomodulator of meta-chlorobenzhydryl urea or 1-o-fluorobenzoyl-5-phenyl-5-ethyl-barbituric acid in an effective concentration 10 μg / ml, subsequent washing of splenocytes and intravenous administration of the obtained splenocytes to syngeneic alcoholized mice in an amount of 15×106⁶ cells per mouse.

EFFECT: restoration of functional activity of splenocytes, altered due to prolonged toxic effects of ethanol and can be used to relieve pathological symptoms in alcohol dependence.

1 cl, 6 ex, 6 dwg

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RU 2 744 411 C1

Authors

Markova Evgeniya Valerevna

Savkin Ivan Vladimirovich

Dates

2021-03-09—Published

2020-03-25—Filed