CARBOHYDRATE-CONTAINING CATIONIC AMPHIPHILES, CAPABLE OF DELIVERING NUCLEIC ACID IN MAMMAL CELLS Russian patent published in 2010 - IPC C07H15/04 A61K9/127 C07C235/38 

Abstract RU 2394834 C1

FIELD: chemistry.

SUBSTANCE: invention relates to carbohydrate-containing polycationic amphiphiles (1-3) which are trihydrochlorides of rac-N-[6-(β-D-glycopyranosyloxy)hexyl]-N-[2,3-di(tetradecyloxy)prop-1-yl]-4-[(12-amino-4,9-diazadodec-1-yl)amino-succinylamino]benzenesulfonamide of the given general formula , where A is a 1,2-di-O-tetradecyl-rac-glycerin residue, B is a galactose residue (for (1)), galactose (for (2)) and mannose (for (3)), C is a spermine residue, n= 6, m = 2.

EFFECT: obtaining compounds which are capable of delivering nucleic acid into mammal cells.

1 cl, 4 tbl, 2 dwg, 11 ex

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RU 2 394 834 C1

Authors

Maslov Mikhail Aleksandrovich

Medvedeva Dar'Ja Alekseevna

Vlasov Valentin Viktorovich

Zenkova Marina Arkad'Evna

Morozova Nina Georgievna

Serebrennikova Galina Andreevna

Dates

2010-07-20Published

2009-06-29Filed