FIELD: medicine, pharmaceutics.
SUBSTANCE: described is injected formed in situ depot-composition, which includes absorbable polymer, polyethyleneglycol with molecular weight 450<MW<650 Da and with end groups, selected from methoxy and ethoxy, characterised by temperature of consolidation between 8° and 20°C, pharmaceutically active substance and, optionally, auxiliary substance. Pharmaceutically active substance is selected from small organic molecules, peptides, polypeptides, proteins, carbohydrates, oligonucleotides, DNA and RNA. Preferably, active substance is somatostatin analogue. Preferably polyethyleneglycol dimethyl ether with molecular weight 500 Da is applied.
EFFECT: compositions by invention are stable in storing, are injected without difficulties, are characterised by low haemolytic and toxic potential.
19 cl, 8 dwg, 2 tbl, 8 ex
