FIELD: medicine, pharmaceutics.
SUBSTANCE: carrier composition for nucleic acid delivery contains (A) a cationic lipid with a steroid skeleton and (B) a cationic lipid of quaternary ammonium salt type. The component (A) represents 3β-[N-(N',N'-dimethylaminoethane)carbamoyl]cholesterol and/or iodide 3β-[N',N',N'-trimethylaminoethane]cholesterol, the component (B) is at least one member selected from a group consisting of dimethyldioctadecylammonium bromide salt, dioleoyltrimethylammonium propane and hydrochloride N-(1-(2,3-bis(oleoyloxy)propyl)-N,N,N-trimethylammonium. The component (B) is contained in the composition in the proportion 10 to 200 weight parts in 100 weight parts of the component (A). The carrier composition is intended for nucleic acid delivery into a cell.
EFFECT: carrier composition is characterised by low toxicity, effectively delivers nucleic acids into the cells, protecting acid from degradation.
10 cl, 5 dwg, 2 tbl, 4 ex
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