SOLUTION FOR PERFUSION AND/OR PRESERVATION OF ORGANS AND WAYS OF ITS APPLICATION Russian patent published in 2010 - IPC A01N1/02 A61K38/04 

FIELD: medicine.

SUBSTANCE: this invention relates to the pharmaceutical industry, in particular to the solution for perfusion, preservation and/or reperfusion of organs, especially heart, for the purpose of transplantation. The solution contains at least one peptide inhibitor of protein kinase C βII (PKC βII), representing the SEQ ID No:l, and/or at least one peptide inhibitor of protein kinase C ζ, (PKC ζ), representing SEQ ID No:2 or Go6983 and/or, at least one peptide activator of protein kinase C δ (PKC δ), representing SEQ ID No:2. Also methods of application the solution are described, including the method of preservation of organ for transplantation, protection of ischemic body from injury, reduction of organ dysfunction after ischemia, preserving release of nitric oxide in ischemic organ, and protection of the body from damage when isolated from circulation.

EFFECT: this invention enables to protect more effectively the transplanted organ from reperfusion injury after ischemia.

98 cl, 24 dwg, 3 ex