FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of 5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxamide and/or one of its physiologically acceptable salts, characterised by that a compound of formula (I),
, in which L is CI, Br, I, SO2F, SO2CF3, SO2C2F5, is reacted with 3-(4-piperazin-1-ylbutyl)indole-5-carbonitrile through transition metal catalysed combination through complex compounds of Pd and/or that the formed 5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxamide is converted to one of its acid addition salt through treatment with an acid, and to a second method which is characterised by that a formula (II) compound, as a base or salt HX (where X=Cl, Br), is reacted with 3-(4-oxobutyl)-1H-indole-5-carbonitrile through reductive amination, and or that 5-(4-[4-(5-cyano-3-indolyl)butyl]-1-piperazinyl)benzofuran-2-carboxamide is converted to one of its acid addition salt through treatment with an acid.
EFFECT: obtaining a compound which is a 5-HT1A receptor agonist.
4 cl, 2 ex
