AMINO ALCOHOL DERIVATIVES Russian patent published in 2010 - IPC C07C317/46 C07C317/48 C07D213/38 A61K31/18 A61P13/10 

FIELD: chemistry.

SUBSTANCE: in formula is or , is , R¹ is hydrogen, halogen, nitro or amino, R² is hydrogen or lower alkyl, R³ is hydrogen, -X- is where -Y- is a bond, -O-, -NH- or -CH₂-, and R⁴, R⁵ and R⁶ each denotes hydrogen, R⁷ is (C₁-C₈)-alkyl, (C₃-C₈)-cycloalkyl, -Z-R⁹ or , where -Z- is -O- or -S-, and each R⁹ independently denotes (C₁-C₈)-alkyl, (C₃-C₈)-cycloalkyl, and R⁸ is -D-E-R¹⁰, in which -D- is -CONHSO₂-, E is (C₁-C₆)-alkylene and R¹⁰ denotes -O-R¹¹ in which R¹¹ is hydrogen. The invention also relates to use of said compounds to prepare a medicinal agent, a pharmaceutical composition and a method of preventive and/or therapeutic treatment of overactive bladder and/or acraturesis.

EFFECT: derivatives are highly effective.

7 cl, 56 ex