POLYHETEROCYCLIC COMPOUNDS USED AS HIGHLY EFFECTIVE INHIBITORS OF HEPATITIS C VIRUS Russian patent published in 2014 - IPC C07D491/56 A61P31/14 

FIELD: chemistry.

SUBSTANCE: invention relates to novel polyheterocyclic compounds of formulas Ia or Ib, given below, stereoisomers, pharmaceutically acceptable salts or their mixture, where m=0.1 or 2; n=0.1 or 2; p=0.1 or 2; q=0.1 or 2; r=0. 1, 2 or 3; stands for a single bond or a double bond; and stands for a double bond in a macrocyclic internal combination with cyclopropyl formyl; stands for a single bond in a cycle D, E, E¹ and G, where D and G independently stand for oxygen, E and E¹ independently stand for C(Ra)(Rb); R¹⁰ stands for hydrogen; Ra, Rb and Rc independently on each other stand for hydrogen; when r=0 E is absent, D and E¹ are directly bound; L stands for methylene (CRbRc); T stands for nitrogen (N) or CH; U stands for carbon (C); W stands for oxygen; X stands for oxygen; Y stands for nitrogen (N) or CH; Z stands for OH; C₁-C₂₀ alkyl-sulphonylamido, C₃-C₂₀-cycloalkyl-sulphonylamido; R¹ and R² independently stand for C₁-C₂₀-alkyl, C₃-C₂₀ cycloalkyl, C₆-C₁₂ arylamine, C₁-C₂₀ alkoxycarbonyl-amino, C₂-C₂₀ heterocyclic sulphonylamide ring; R³, R⁴, R⁵, R⁶ - independently stand for H; R⁷, R⁸ and R⁹ independently stand for H. The compounds inhibit replication of protease NS3 of the hepatitis C virus.

EFFECT: improved properties of the compounds.

7 cl, 1 tbl, 11 dwg, 118 ex