RNA DUPLEX CAPABLE OF INTERFERENCE AND HAVING BLUNT ENDS AND 3'-MODIFICATIONS Russian patent published in 2010 - IPC C12N15/11 A61K48/00 

FIELD: medicine.

SUBSTANCE: invention refers to compounds represented by double-strained RNA mediating RNA interference and including two complementary RNA-strands containing 17-30 nucleotides with at least one blunt end which includes 3'-end of formula I: , where X means O or S, R₁ and R₂ independently mean OH, NH₂, SH, alkyl, aryl, alkylaryl, arylalkyl, where alkyl, aril, alkylaryl, arylalkyl are optionally substituted with additional heteroatoms and functional groups where the specified heteroatom is chosen from the group including N, O and S, and the specified functional group is chosen from the group, including OH, NH₂, SH, carboxylic acid and ester, or R₁ and R₂ can have formula Y-Z wherein Y means O, N, S, and Z means N, alkyl, aryl, alkylaryl, arylalkyl where alkyl, aryl, alkylaryl, arylalkyl are optionally substituted with additional heteroatoms where the specified heteroatom is chosen from the group including N, O and S; provided that both R₁ and R₂ does not mean OH.

EFFECT: offered invention allows eliminating the disadvantages of synthetic siRNA with 3'-overhanging ends.

8 cl, 4 dwg, 1 tbl, 3 ex