FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine, namely to gastroenterology, and can be used for treatment of intestinal diseases. For this purpose applied is intrarectal introduction of compounds which cause RNA interference. In addition, claimed are RNKi compounds with specified nucleotide sequence, causing RNA-interference and intended for intrarectal introduction, whose target is interleukin-12 gene. Claimed compounds can also be used for treatment of intestinal diseases.
EFFECT: inventions ensure efficient disease treatment due to efficient reaching and impact in action targets.
43 cl, 1 tbl, 5 ex, 9 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| siPHK-BASED TREATMENT OF EYE DISEASE CHARACTERISED BY HIGH INTRAOCULAR PRESSURE | 2005 |
|
RU2407531C2 |
| TREATMENT OF CNS DISORDERS | 2007 |
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| siRNA AND THEIR USE IN METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF ORAI1 GENE | 2014 |
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| METHODS AND COMPOSITIONS FOR INHIBITING EXPRESSION OF P2X7 RECEPTOR | 2005 |
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| OLIGIRIBONUCLEOTIDES AND METHODS OF THEIR APPLICATION FOR TREATMENT OF ACUTE RENAL FAILURE AND OTHER DISEASES | 2005 |
|
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| 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1 EXPRESSION MODULATION FOR TREATING EYE DISEASES | 2006 |
|
RU2420582C2 |
| OLIGORIBONUCLEOTIDES AND METHODS OF THEIR APPLICATION FOR TREATMENT OF ACUTE RENAL FAILURE | 2005 |
|
RU2584609C2 |
| MI-RNA AND THEIR USE IN METHODS AND COMPOSITIONS FOR TREATMENT AND / OR PREVENTION OF EYE CONDITIONS | 2013 |
|
RU2663100C2 |
| POLYCONJUGATES FOR POLYNUCLEOTIDE INTRODUCTION IN VIVO | 2007 |
|
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| KIRNA AND THEIR USE IN THE METHODS AND COMPOSITIONS FOR TREATMENT AND/OR PREVENTION OF EYE DISEASES | 2012 |
|
RU2653766C2 |
