POLYCONJUGATES FOR POLYNUCLEOTIDE INTRODUCTION IN VIVO Russian patent published in 2011 - IPC A61K47/30 A61K31/7088 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to compositions which can be applied to introduce polynucleotides or other molecules which are not characterised by ability to penetrate into cells of mammal molecules. The offered composition intended for molecule introduction in a cell, contains a conjugate of formula: N-L¹-P-(L²-M)_y in which N means a molecule not characterised by ability to penetrate through membranes or a molecule having low ability to penetrate through the membrane; L¹ means a first reversible bond containing a bond labile in a physiological environment; P means a polymer exhibiting activity on the membrane; L² means a second reversible bond containing an orthogonal bond labile in the physiological environment; M means a masking agent selected from the group including steric stabilisers transferring the group directly, and charge-modifying agents, and y means an integer exceeding 0.

EFFECT: polyconjugate systems are characterised by types of activity which provide the directed transfer, exhibit antiopsonising, antiaggregation and transfection action, in small biocompatible carriers intended for introduction in vivo.

18 cl, 26 ex, 36 dwg