CAPTURING OF ENDOTHELIAL PRECURSOR-CELLS BY MEDICATION-ELUTING IMPLANTED MEDICAL DEVICE Russian patent published in 2010 - IPC A61L27/28 A61L27/34 A61L27/54 A61F2/02 A61F2/82 

FIELD: medicine.

SUBSTANCE: there is described medical device for implantation into vessels or lumen structures in body, which stimulates positive reconstruction of blood vessels. Medical device, such as stent and synthetic transplant, is covered with pharmaceutical composition, consisting of matrix with controlled release and one or several pharmaceutical substances intended for direct delivery of medications into surrounding tissues. In addition, coating on medical device contains ligand, such as peptide, antibody or small molecule, in tended for capturing of precursor-cells on contacting with blood device surface for restoration of endothelium on stenosis site. In particular, covered with medication stents are intended for application, for instance in procedures of balloon angioplasty for prevention or inhibition of re-stenosis.

EFFECT: device represents biologically compatible system for delivery of therapeutic medications locally in safe and controlled manner.

24 cl, 57 dwg, 2 tbl, 11 ex