MEDICATION, REDUCING DESIRE FOR ALCOHOL, PHARMACEUTICAL COMPOSITION AND METHODS OF ITS OBTAINING, MEDICATION AND TREATMENT METHOD Russian patent published in 2010 - IPC C07D235/28 C07D403/12 C07D413/12 C07D405/12 C07D403/04 C07D401/12 C07D401/14 C07D487/04 C07D409/12 A61K31/4164 A61K31/496 A61K31/5377 A61K31/454 A61K31/4245 A61K31/4192 A61K31/4439 A61K31/4985 A61P25/32 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to medication, reducing desire for alcohol, which represents substituted 1H-benzimidazoles of general formula 1 or their pharmaceutically acceptable salts and/or hydrates, pharmaceutical composition, and medication on their basis. Compounds can be applied in treatment of alcohol abuse with application of ethanol-containing products, if necessary, together with antidepressants. In compounds of general formula 1 , where: W represents sulfur atom or group S=O; R¹ represents one or more substituents, selected from hydrogen, halogen, C₁-C₄alkyl, C₁-C₄alkyloxy, optionally substituted 5-6-member azaheterocyclyl with 1-2 atoms of nitrogen and/or oxygen in cycle; R² represents atom of hydrogen or optionally substituted C₁-C₄alkyl; R³ and R⁴ independently on each other represent optionally similar substituents, selected from hydrogen, optionally substituted C₁-C₄alkyl, C₃-C₆cycloalkyl; R⁵ represents alkyl substituent, selected from hydrogen or optionally substituted C₁-C₇alkyl, C₁-C₇alkenyl, C₁-C₄alkynyl, optionally substituted phenyl, optionally substituted 5-6-member heterocyclyl with 1-3 heteroatoms, selected from nitrogen, oxygen and sulfur, possibly condensed with benzene ring; C₁-C₄-alkoxycarbonyl, optionally substituted amino carbonyl, or group CR³R⁴R together stands for group , where Alk stands for C₁-C₄alkyl.

EFFECT: medication allows to reduce symptoms of alcohol abuse considerably as compared with earlier known compounds and does not produce unfavorable effect on liver function.

12 cl, 3 tbl, 2 ex, 1 dwg