PYRIDAZINE DERIVATIVES Russian patent published in 2010 - IPC C07D237/28 C07D237/26 C07D403/04 C07D417/04 C07D237/08 A61K31/50 A61K31/501 A61K31/502 A61K31/504 A61P3/10 A61P3/06

Abstract RU 2401832 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compounds of formula I: and their pharmaceutically acceptable salts, in which R¹-R⁴ have values, given in item 1 of invention formula. Said compounds possess inhibiting activity with respect to 11-beta-hydroxysteroid-dehydrogenase and can be applied for production of medications, intended for treatment and prevention of diabetes, especially, diabetes of II type, obesity, malnutrition and hypertension.

EFFECT: development of efficient method of obtaining formula I compounds and based on them pharmaceutical composition.

25 cl, 1 tbl, 149 ex

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RU 2 401 832 C2

Authors

Amrajn Kurt

Khuntsiker Daniel'

Kun Bernd

Majveg Aleksander F.

Najdkhardt Verner

Dates

2010-10-20—Published

2006-06-26—Filed