ALKYL-PYRIDAZINE DERIVATIVES AS INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1(11β-HSD 1) Russian patent published in 2011 - IPC C07D237/26 A61K31/502 A61P3/10 

FIELD: chemistry.

SUBSTANCE: described are compounds of formula I , where R¹ and R², together with carbon atoms C^a and C^b to which they are bonded, form or R³, R⁵, R⁶ and R⁷ independently denote hydrogen, C₁-C₆alkyl or C₃-C₈cycloalkyl; and R⁴ denotes 2,2-dimethylpropyl, 3-methylbutyl, isopropyl, tert-butyl, cyclopropylmethyl, cyclopentylmethyl, 3,3-dimethylbutyl or 1-cyclopropyl-1-methylethyl. The invention also relates to pharmaceutically acceptable salts of such compounds and pharmaceutical compositions containing such compounds of salts thereof. The disclosed compounds and compositions are capable of inhibiting activity of the 11-β-hydroxysteroid dehydrogenase 1 (11-β-HSD1) enzyme.

EFFECT: possibility of using derivatives for treating and preventing diabetes, obesity, eating disorders, dyslipidaemia and hypertension.

22 cl, 1 tbl, 27 ex