METHOD OF DETERMINING BIOCOMPATIBILITY OF FOREIGN MATERIAL WITH ORGANISM Russian patent published in 2010 - IPC G01N33/48 G01N33/573 G01N33/15 

FIELD: medicine.

SUBSTANCE: to realise method of determining biocompatibility of organism with foreign material, before its introduction into organism sampling of analysed material from individual is carried out, foreign material in form of powder with particle size from 0.5 to 1 mm³ in amount 500 mcg is added directly into cell substance and cytochemical parametres of fermentative activity of cells before and after introduction of foreign material into cell substance are determined. Fermentative activity of cells is determined by not less than 5 parametres, after three time intervals, by determining optic density of cell substance, obtained values being expressed in form of stimulation index, after which calculated is mean value of stimulation index of each separate cytochemical parametre of cell substance reaction to each foreign material. After that said parametres separately on each foreign material are summed up, using only integer part of stimulation index number, scale of biocompatibility is built and used to make conclusion about degree of compatibility of each separate foreign material and particular organism. The less is total index of stimulation, the more foreign material is biocompatible with organism.

EFFECT: improvement of method.

5 cl, 17 tbl, 3 ex