FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, specifically to a method for synthesis of N,N-dimethyl-N-(4-quinolinylmethyl)amine of formula
, which involves reaction of o- iodoaniline with c N1,N1,N4,N4-tetramethyl-2-butyne-1,4-diamine in the presence of lithium chloride salt (LiCl), potassium carbonate (K2CO3), palladium catalyst Pd(OAc)2, in molar ratio of o-iodoaniline: N1,N1,N4,N4-tetramethyl-2-butyne-1,4-diamine: LiCl: K2CO3: Pd(OAc)2=10:(10-14):10:50:(0.3-0.7) at temperature of 100°C and atmospheric pressure for 18-22 hours in dimethyl formamide as a solvent.
EFFECT: novel method for synthesis of said compound, characterised by high output of the desired product.
1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING N,N,N,N-TETRAMETHYLBUTANE DITHIOAMIDE | 2009 |
|
RU2433996C2 |
| METHOD OF PRODUCING N,N,N,N-TETRAMETHYL-2-BUTYNE-1,4-DIAMINE | 2008 |
|
RU2408572C2 |
| METHOD FOR COMBINED SYNTHESIS OF 4-ALKYLQUINOLINE AND (2,3-DIALKYL-4-QUINOLINYL)-N, N-DIMETHYLMETHANE AMINE | 2009 |
|
RU2440341C2 |
| METHOD OF PRODUCING N,N,N,N-TETRAMETHYL-2-BUTYNE-1,4-DIAMINE | 2010 |
|
RU2448951C2 |
| METHOD OF PRODUCING N,N,N,N-TETRAMETHYL-2-BUTENE-1,4-DIAMINE | 2008 |
|
RU2440329C2 |
| METHOD OF PRODUCING α,ω-BIS-[2-(N,N-DIMETHYLAMINO)THIEN-5-YL]ALKANES | 2010 |
|
RU2434012C2 |
| METHOD FOR PREPARING N-(1,5,3-DITHIAZOCYNAN-3-YL)AMIDES | 2012 |
|
RU2496777C2 |
| METHOD OF PRODUCING N-(1,5,3-DITHIAZEPAN-3-YL)AMIDES | 2011 |
|
RU2482114C2 |
| METHOD OF PRODUCING N,N,N,N-TETRAMETHYLALKADIYNEDIAMINES | 2007 |
|
RU2373189C2 |
| METHOD OF OBTAINING N-(1,5,3-DITHIAZONAN-3-YL)AMIDES | 2012 |
|
RU2516696C1 |
