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2 440 341

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IPC

C07D215/04(2006-01-01)

C07D215/12(2006-01-01)

(21) (22)

Application

2009145314/04, 2009-12-07

(24)

Start date

2009-12-07

(22)

Actual filing date

2009-12-07

(45)

Published

2012-01-20

(72)

Inventor

Dzhemilev Usein MemetovichShajbakova Marija Gennad'EvnaMakhmudijarov Gilemdar AdykhamovichIbragimov Askhat GabdrakhmanovichKhalilov Leonard Mukhibovich

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Neftekhimii I Kataliza Ran

METHOD FOR COMBINED SYNTHESIS OF 4-ALKYLQUINOLINE AND (2,3-DIALKYL-4-QUINOLINYL)-N, N-DIMETHYLMETHANE AMINE Russian patent published in 2012 - IPC C07D215/04 C07D215/12

Abstract RU 2440341 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a method for combined synthesis of 4-alkylquinoline and (2,3-dialkyl-4-quinolinyl)-N,N-dimethylmethane amine of formula (1) and (2), which involves reaction of o-iodoaniline with N,N-dimethyl-2-alkyne-1-amine (where the alkyne is heptyne, octyne, undecyne) in the presence of lithium chloride (LiCl), potassium carbonate (K₂CO₃) and a palladium catalyst Pd(OAc)₂ in molar ratio of o-iodoaniline: N,N-dimethyl-2-alkyne-1-amine: LiCl: K₂CO₃: Pd(OAc)₂=10:(25-35):10:(25-35):(0.5-1.0), at temperature 90-110°C and atmospheric pressure, preferably at 100°C for 18-22 hours in dimethyl formamide as a solvent.

EFFECT: novel method for combined synthesis of 4-alkylquinoline and 2,3-dialkyl-4-quinolinyl-N,N-dimethylmethane amine, which can be used in fine organic synthesis.

1 cl, 1 tbl, 1 ex

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RU 2 440 341 C2

Authors

Dzhemilev Usein Memetovich

Shajbakova Marija Gennad'Evna

Makhmudijarov Gilemdar Adykhamovich

Ibragimov Askhat Gabdrakhmanovich

Khalilov Leonard Mukhibovich

Dates

2012-01-20—Published

2009-12-07—Filed