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IPC

C12N15/00(2006-01-01)

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Application

2009126235/10, 2009-07-09

(24)

Start date

2009-07-09

(22)

Actual filing date

2009-07-09

(45)

Published

2010-11-20

(72)

Inventor

Kozlov Sergej AleksandrovichAndreev Jaroslav AlekseevichMurashev Arkadij NikolaevichGrishin Evgenij Vasil'Evich

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Bioorganicheskoj Khimii Im. Akademikov M.M. Shemjakina I Ju.A. Ovchinnikova Ran

ACTINIA POLYPEPTIDE, POSSESSING ANALGESIC ACTION Russian patent published in 2010 - IPC C12N15/00

Abstract RU 2404245 C1

FIELD: medicine.

SUBSTANCE: there is claimed actinia polypeptide, demonstrating analgesic activity, whose amino acid sequence is expressed by formula: H₂N-Gly¹-Ser²-Ile³-Cys⁴-Leu⁵-Glu⁶-Pro⁷-Lys⁸-Val⁹-Val¹⁰-Gly¹¹-Pro¹²-Cys¹³-Thr¹⁴-Ala¹⁵-Tyr¹⁶-Phe¹⁷-Xl¹⁸-Arg¹⁹-Phe²⁰-Tyr²¹-Phe²²-X2²³-Ser²⁴-Glu²⁵-Thr²⁶-Gly²⁷-Lys²⁸-Cys²⁹-Thr³⁰-Pro³¹-Phe³²-Ile³³-Tyr³⁴-Gly³⁵-Gly³⁶-Cys³⁷-Glu³⁸-Gly³⁹-Asn⁴⁰-Gly⁴¹-Asn⁴²-Asn⁴³-Phe⁴⁴-Glu⁴⁵-Thr⁴⁶-Leu⁴⁷-Arg⁴⁸-Ala⁴⁹-Cys⁵⁰-Arg⁵¹-X3⁵²-Ile⁵³-Cys⁵⁴-Arg⁵⁵-Ala⁵⁶-COOH, where amino acid residue X1 corresponds to Arg, amino acid residue X2 corresponds to Asp and amino acid residue X3 corresponds to Ala; or amino acid residue X1 corresponds to Pro, amino acid residue X2 corresponds to Asn and amino acid residue X3 corresponds to Gly.

EFFECT: invention makes it possible to extend assortment of analgesic medications, which have directed action on cell target.

18 dwg, 1 tbl, 13 ex

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RU 2 404 245 C1

Authors

Kozlov Sergej Aleksandrovich

Andreev Jaroslav Alekseevich

Murashev Arkadij Nikolaevich

Grishin Evgenij Vasil'Evich

Dates

2010-11-20—Published

2009-07-09—Filed