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2 521 657

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IPC

C07K14/435(2006-01-01)

A61K38/00(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2013113891/10, 2013-03-28

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Start date

2013-03-28

(22)

Actual filing date

2013-03-28

(45)

Published

2014-07-10

(72)

Inventor

Kozlov Sergej AleksandrovichOsmakov Dmitrij IgorevichAndreev Jaroslav AlekseevichKoshelev Sergej Gennad'EvichGrishin Evgenij Vasil'EvichD'Jachenko Igor' AleksandrovichBondarenko Dmitrij AleksandrovichMurashev Arkadij Nikolaevich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Biorganicheskoj Khimii Im. Akademikov M.M. Shemjakina I Ju.A. Ovchinnikova Rossijskoj Akademii Nauk Ran)

ANALGESIC PEPTIDE FROM SEA ANEMONE URTICINA GREBELNYI Russian patent published in 2014 - IPC C07K14/435 A61K38/00 A61P29/00

Abstract RU 2521657 C1

FIELD: chemistry.

SUBSTANCE: analgesic peptide has the following amino acid sequence: H₂N-Ile¹-Ser²-Ile³-Asp⁴-Pro⁵-Pro⁶-Cys⁷-Arg⁸-Phe⁹-Cys¹⁰-Tyr^ll-His^l2-Arg¹³-Asp^l4-Gly^l5-Ser^l6-Gly^l7-Asn^l8-Cys¹⁹-Val²⁰-Tyr²¹-Asp²²-Ala²³-Tyr²⁴-Gly²⁵-Cys²⁶-Gly²⁷-Ala²⁸-Val²⁹-COOH. Said peptide can be used as a medicinal agent for treating pathologies associated with tissue acidosis and treating neurologic diseases associated with ASIC3 receptor function, as well as for determining the topology and molecular mechanisms of the function of the ASIC3 channel, and in test systems for detecting and testing novel anti-pain preparations, agonists and antagonists of the ASIC3 receptor.

EFFECT: analgesic action owing to inhibition of the functional activity of proton-activated ion channels.

9 dwg, 11 ex

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RU 2 521 657 C1

Authors

Kozlov Sergej Aleksandrovich

Osmakov Dmitrij Igorevich

Andreev Jaroslav Alekseevich

Koshelev Sergej Gennad'Evich

Grishin Evgenij Vasil'Evich

D'Jachenko Igor' Aleksandrovich

Bondarenko Dmitrij Aleksandrovich

Murashev Arkadij Nikolaevich

Dates

2014-07-10—Published

2013-03-28—Filed