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2 614 759

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IPC

C07K14/435(2006-01-01)

A61K38/17(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2016104705, 2016-02-12

(24)

Start date

2016-02-12

(22)

Actual filing date

2016-02-12

(45)

Published

2017-03-29

(72)

Inventor

Kozlov Sergej AleksandrovichAndreev Yaroslav AlekseevichGrishin Evgenij VasilevichLogashina Yuliya AleksandrovnaKorolkova Yuliya VladimirovnaMosharova Irina VladimirovnaMurashev Arkadij Nikolaevich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Bioorganicheskoj Khimii Im. Akademikov M.M. Shemyakina I Yu.A. Ovchinnikova Rossijskoj Akademii Nauk Ran)

ANALGESIC PEPTIDE OF SEA ANEMONE Russian patent published in 2017 - IPC C07K14/435 A61K38/17 A61P29/00

Abstract RU 2614759 C1

FIELD: biotechnology.

SUBSTANCE: invention relates to biologically active peptide of sea anemone Metridium senile, having the following amino acid sequence H₂N-Asn^l-Ile²-Ile³-Val⁴-Gly⁵-Gly⁶-Cys⁷-Ile⁸-Lys⁹-Cys¹⁰-His¹¹-Val¹²-Lys¹³-Asn¹⁴-Ala¹⁵-Ser¹⁶-Gly¹⁷-Arg¹⁸-Cys¹⁹-Val²⁰-Arg²¹-Ile²²-Val²³-Gly²⁴-Cys²⁵-Gly²⁶-Val²⁷-Asp²⁸-Lys²⁹-Val³⁰-Pro³¹-Asp³²-Leu³³-Phe³⁴-Ser³⁵-COOH. The peptide can be used as a medicament alone or in conjunction with other components to relieve pain conditions in humans and animals stipulated by participation of TRPA1 receptors, as well as for clarification of topology and molecular mechanisms of TRPA1 channels functioning, studying of TRPA1 channels distribution in living organisms, in test systems for detection and testing of new drugs against pain and/or inflammation, TRPA1 receptor agonists and antagonists, or for production of antibodies used for scientific and medical purposes.

EFFECT: increase of analgesic effect by inhibiting the functional activity of ion channel TRPA1.

10 dwg, 13 ex

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RU 2 614 759 C1

Authors

Kozlov Sergej Aleksandrovich

Andreev Yaroslav Alekseevich

Grishin Evgenij Vasilevich

Logashina Yuliya Aleksandrovna

Korolkova Yuliya Vladimirovna

Mosharova Irina Vladimirovna

Murashev Arkadij Nikolaevich

Dates

2017-03-29—Published

2016-02-12—Filed