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2 475 497

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C1

(51)

IPC

C07K14/435(2006-01-01)

A61K38/17(2006-01-01)

A61P29/00(2006-01-01)

(21) (22)

Application

2012108499/10, 2012-03-05

(24)

Start date

2012-03-05

(22)

Actual filing date

2012-03-05

(45)

Published

2013-02-20

(72)

Inventor

Kozlovskaja Ehmma PavlovnaMonastyrnaja Margarita MikhajlovnaGladkikh Irina NikolaevnaTabakmakher Valentin MikhajlovichKrivoshapko Ol'Ga NikolaevnaKozlov Sergej AleksandrovichOsmanov Dmitrij IgorevichAndreev Jaroslav AleksandrovichKoshelev Sergej Gennad'EvichGrishin Evgenij Vasil'Evich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Tikhookeanskij Institut Bioorganicheskoj Khimii Im. G.B. Eljakova Dal'Nevostochnogo Otdelenija Rossijskoj Akdemii Nauk Dvo Ran)Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Institut Bioorganicheskoj Khimii Im. Akademikov M.M. Shemjakina I Ju.A. Ovchinnikova Rossijskoj Akademii Nauk Ran)

POLYPEPTIDE FROM SEA ANEMONE HETERACtis crispa, HAVING ANALGESIC ACTION Russian patent published in 2013 - IPC C07K14/435 A61K38/17 A61P29/00 

Abstract RU 2475497 C1

FIELD: chemistry.

SUBSTANCE: invention relates to biochemistry and specifically to biologically active polypeptides having analgesic action. Disclosed is a polypeptide π-AnmTX Her 1b-1, having analgesic action and having the following amino acid sequence: H2N-Gly1-Thr2-Pro3-Cys4-Lys5-Ces6-His7-Gly8-Tyr9-He10-Gly11-Val12-Tyr13-Trp14-Phe15-Met16-Leu17-Ala18-Gly19-Cys20-Phe21-Asn22-Gly23-lyr24-Gly25-lyr26-Asn27-Leu28-Ser29-Cys30-Phc31-lyr32-Phe33-Leu34-Gly35-He36-Cys37-Cys38-Val39-Asp40-Arg41-COOH.

EFFECT: invention can be used in medicine to treat channelopathies associated with tissue acidosis and for identification of topology and molecular mechanisms of the functioning of the ASIC3 channel.

4 dwg, 4 ex

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RU 2 475 497 C1

Authors

Kozlovskaja Ehmma Pavlovna

Monastyrnaja Margarita Mikhajlovna

Gladkikh Irina Nikolaevna

Tabakmakher Valentin Mikhajlovich

Krivoshapko Ol'Ga Nikolaevna

Kozlov Sergej Aleksandrovich

Osmanov Dmitrij Igorevich

Andreev Jaroslav Aleksandrovich

Koshelev Sergej Gennad'Evich

Grishin Evgenij Vasil'Evich

Dates

2013-02-20—Published

2012-03-05—Filed

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