FIELD: chemistry.
SUBSTANCE: invention relates to an improved method for synthesis of 2-(benzylthio)pyrimidine-4,6 (1H, 5H) dione of formula 
. Said compound can be used as an intermediate product in preparation of medicinal agents. The method involves reaction of a sodium salt obtained from condensation reaction of thiourea with malonic ester in the presence of sodium methylate, which is then dissolved in aqueous dioxane, preferably 50%, and then reacted with benzyl chloride in molar ratio 1:1.1 at room temperature, preferably 25°C, for 2 hours.
EFFECT: method simplifies the process and enables to obtain the desired product with high output.
2 ex
| Title | Year | Author | Number |
|---|---|---|---|
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|
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RU2083567C1 |
| 0 |
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SU1781216A1 | |
| METHOD OF SYNTHESIS OF THIOBARBITURIC ACID | 1994 |
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