FIELD: chemistry.
SUBSTANCE: invention relates to an improved method for synthesis of 2-(benzylthio)pyrimidine-4,6 (1H, 5H) dione of formula 
. Said compound can be used as an intermediate product in preparation of medicinal agents. The method involves reaction of a sodium salt obtained from condensation reaction of thiourea with malonic ester in the presence of sodium methylate, which is then dissolved in aqueous dioxane, preferably 50%, and then reacted with benzyl chloride in molar ratio 1:1.1 at room temperature, preferably 25°C, for 2 hours.
EFFECT: method simplifies the process and enables to obtain the desired product with high output.
2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 2-METHYLPYRIMIDINE-4,6-(3H,5H)-DIONE | 2012 |
|
RU2503666C1 |
| METHOD FOR PREPARING DERIVATIVES OF THIOBARBITURIC ACID | 2000 |
|
RU2242467C2 |
| METHOD FOR SYNTHESIS OF 5-(4-OXO-2-THIOXO-1,3;4,5-TETRAHYDRO-2H-CHROMENO[2,3-d]PYRIMIDIN-5-YL)-2-THIOXODIHYDROPYRIMIDINE-4,6(1H,5H)-DIONE | 2009 |
|
RU2412189C1 |
| DERIVATIVES OF ARYLSULFONEAMIDE OR THEIR SALTS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIPROTECTIVE, ANTIHYPERTENSION AND VASOSPAMOLYTIC, IN PART, ANTIISCHEMIC ACTION | 1992 |
|
RU2083567C1 |
| METHOD OF PREPARING 2-THIOBARBITURC ACID | 1997 |
|
RU2161152C2 |
| METHOD OF PRODUCING 2-METHYLPYRIMIDINE-4,6-(3H,5H)-DIONE | 2011 |
|
RU2461545C1 |
| SODIUM SALT OF 4-{ 2-[2-(4- HYDROXY-3-METHOXYPHENYL)-VINYL]-6-ETHYL-4-OXO-5-PHENYL-4H-PYRIMIDINE-1-YL} -BENZENESULFAMIDE, WHICH HAS AN ANTITUMOR EFFECT | 2021 |
|
RU2763899C1 |
| 0 |
|
SU434084A1 | |
| METHOD OF PRODUCING 2-METHYLPYRIMIDINE-4,6-(3H,5H)-DIONE | 2012 |
|
RU2503665C1 |
| CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | 2008 |
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RU2479584C2 |
