ANTIBACTERIAL QUINOLINE DERIVATIVES Russian patent published in 2012 - IPC C07D215/22 A61K31/47 A61P31/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new substituted quinoline derivatives of general formula

, including any their stereochemical isomer forms, and to their pharmaceutically acceptable salts wherein p means an integer equal to 1; q means an integer equal to 1 or 2; R¹ means halogen; R² means C_1-6alkyloxy; R³ means aryl; each R⁴ and R⁵ independently means C_1-6alkyl; or R⁴ and R⁵ together with nitrogen atom whereto attached, form a radical selected from the group consisting of piperidino and piperazino with each radical to be substituted by 1 substitute selected from C_1-6alkyl; R⁶ means aryl¹; R¹⁰ means C_1-6alkyl or aryl C_1-6alkyl; Z means S or NR¹⁰; aryl and aryl¹ represent phenyl. Also, the invention refers to a pharmaceutical composition based on the compound of formula (la), to the use of the compound of formula (la) and to a method for preparing it.

EFFECT: there are prepared new quinoline derivatives of formula (la), effective in treating a bacterial infection.

15 cl, 4 tbl, 3 ex