FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of 4β-amino-4'-demetyl-4-desoxypodophyllotoxin of formula (1), involving the following steps: a) reaction of thiourea and 4β-halogenoacetamido-4'-demethyl-4-desoxypodophyllotoxin in a medium of a weak pure acid or mixture of acid, water an organic solvent without using any other solvent at temperature higher than ambient temperature; b) extraction of 4β-amino-4'-demethyl-4- desoxypodophyllotoxin.
EFFECT: compound is an intermediate product in synthesis of anti-cancer compounds.
22 cl, 1 tbl, 1 ex
| Title |
Year |
Author |
Number |
| METHOD OF SYNTHESIS OF ANTICANCER DERIVATIVES OF (POLY)AMINOALKYLAMINOACETAMIDE EPIPODOFILLOTOXINE |
2008 |
- Gjumehnski Iv
- Grusso Mars'Jal'
- Ehmber T'Erri
|
RU2450009C2 |
| NOVEL (POLY)AMINOALKYLAMINOALKYLAMIDE, ALKYL-UREA OR ALKYL-SULFONAMIDE DERIVATIVES OF EPIPODOPHYLLOTOXIN, METHOD OF OBTAINING THEREOF AND METHOD OF APPLICATION THEREOF IN THERAPY AS ANTI-CANCER MEDICATIONS |
2009 |
- Imber T'Erri
- Guminski Iv
- Barre Zhan-Mark
- Krjuzinski Anna
|
RU2529676C2 |
| 4-AMINO-5-CYANOPYRIMIDINE DERIVATIVES |
2005 |
- Kato Masaja
- Sato Norifumi
- Okada Minoru
- Uno Tetsujuki
- Ito Nobuaki
- Takedzi Jasukhiro
- Sinokhara Khisasi
- Fuva Masakhiro
|
RU2386628C2 |
| METHOD OF PREPARING DERIVATIVES OF 7-/2-(2-AMINOTHIAZOLYL-4)-2-ALKOXYIMINOACETAMIDO/-3-CEPHEM-4-CARBOXYLIC ACID |
0 |
|
SU791246A3 |
| PROCESS FOR PREPARING 4-SUBSTITUTED ANTHRACYCLINONES |
1989 |
- Uolter Kabri[It]
- Sil'Vija De Bernardinis[It]
- Franko Frakalanchi[It]
- Serdzho Penko[It]
|
RU2071463C1 |
| METHOD OF SYNTHESIS 9-AMINO-6-DEMETHYL-6-DEOXYTETRACYCLINE SULFATE (VARIANTS) |
1993 |
|
RU2124000C1 |
| DERIVATIVES OF 4-PHENYLAMINOTHAZOLE, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION |
1996 |
- Daniell' Gjulli
- P'Er Rozhe
- Kamil' Zhorzh Vermut
|
RU2146253C1 |
| METHODS OF SYNTHESIS OF BICYCLIC AMIDINOHYDRAZONES (VARIANTS) AND BICYCLIC HYDROXYAMIDINES |
1993 |
|
RU2126381C1 |
| METHOD FOR PRODUCING AN INTERMEDIATE COMPOUND FOR PRODUCING A 4-METHOXYPYRROL DERIVATIVE |
2018 |
- Shin, Jeong-Taek
- Son, Jeong Hyun
- Lee, Seung Chul
|
RU2737470C1 |
| METHOD OF PRODUCING TWO 4-{[(2S)-2-{4-[5-CHLORO-2-(1H-1,2,3-TRIAZOL-1-YL)PHENYL]-5-METHOXY-2-OXOPYRIDIN-1(2H)-IL} BUTANOYL]AMINO}-2-FLUOROBENZAMIDE DERIVATIVES |
2019 |
- Egger, Julian
- Goetz, Daniel
- Sowa, Michal
|
RU2804663C2 |
