TRIAZOLOPYRIDAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY Russian patent published in 2019 - IPC C07D487/04 A61K31/5025 A61K31/506 A61K31/5377

Abstract RU 2677698 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (IIC) or a pharmaceutically acceptable salt thereof. In formula (IIC), E stands for -CH₂-; V is N; W represents O or C(R³²(R³³)); R¹² is hydrogen; R¹⁵ represents a difluoromethoxy group; R¹⁶ is hydrogen; R²³ is hydrogen; R³² represents a carboxy group; and R³³ is hydrogen. Also the invention relates to a pharmaceutical composition, to the use of a compound, to a method for treating and/or preventing rheumatoid arthritis or Crohn's disease.

EFFECT: obtained are new compounds of formula (IIC), with the properties of the modulator of TNFα activity.

5 cl, 3 ex

Similar patents RU2677698C1

Title	Year	Author	Number
IMIDAZOTHIAZOLE DERIVATIVES AS TNF ACTIVITY MODULATORS	2014	Aleksander Rikki Piter Ali Mezkher Khussejn Braun Dzhulien Alister Dzhekson Viktoriya Elizabet	RU2683940C1
TRIAZOLOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Dzhekson Viktoriya Elizabet	RU2677697C1
BENZOTRIAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Kroplin Boris	RU2677696C1
IMIDAZOPYRIMIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Ali Mezkher Khussejn Brukings Daniel Kristofer Braun Dzhulien Alister Dzhekson Viktoriya Elizabet Kroplin Boris Porter Dzhon Robert	RU2691629C1
TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS TNF ACTIVITY MODULATORS	2014	Dzhekson Viktoriya Elizabet Kroplin Boris Loue Martin Aleksander Porter Dzhon Robert	RU2684635C1
PYRAZOLOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Dzhekson Viktoriya Elizabet Kroplin Boris	RU2684641C1
TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Defej Sabine Kher Yag Paul Dzhekson Viktoriya Elizabet Dzhonson Dzhejms Endryu Kroplin Boris Porter Dzhon Robert	RU2696270C1
IMIDAZOPYRIDAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Ali Mezkher Khussejn Brukings Daniel Kristofer Braun Dzhulien Alister Khatchings Martin Klajv Dzhekson Viktoriya Elizabet Kroplin Boris Porter Dzhon Robert Kuinsi Dzhoanna Rejchel	RU2679609C1
CONDENSED BICYCLIC HETEROAROMATIC DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Aleksander Rikki Piter Foulks Gregori Khatchings Martin Klajv Dzhekson Viktoriya Elizabet Kroplin Boris Ryuberson Dzhejms Tomas Ruk Sera Margaret Chzhu Chzhoanin	RU2685234C1
IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Delini Mikhael Lui Rober Kher Yag Paul Dzhekson Viktoriya Elizabet Kroplin Boris Lekomt Faben Klod Porter Dzhon Robert	RU2678305C1

RU 2 677 698 C1

Authors

Brukings Daniel Kristofer

Dates

2019-01-21—Published

2014-12-08—Filed