ANTI-IFNAR1 ANTIBODIES WITH LOWER LIGAND Fc AFFINITY Russian patent published in 2015 - IPC C07K16/28 C07K16/46 A61K39/395 A61P37/00 C12N15/13

Abstract RU 2556125 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: presented invention refers to immunology. What is presented is a monoclonal anti-IFNAR1 antibodies with L234F, L235E and P331S Fc mutations of human IgG1 possessing a lower affinity to Fcgamma RI, Fcgamma RIIIA and c1q receptors as compared to a non-modified antibody. There are described the recovered nucleic acid providing expression of the above antibody containing a nucleotide sequence coding the antibody, and a pharmaceutical composition based on the above antibody.

EFFECT: using the invention provides the antibody possessing the lower affinity to Fcgamma RI, Fcgamma RIIIA and c1q receptors that provides reducing the undesired effector functions in treating chronic inflammation and autoimmune conditions.

9 cl, 34 dwg, 7 tbl, 36 ex

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RU 2 556 125 C2

Authors

Antoni Kojl

Piter Kiner

Kherren Vu

Rikardo Chibotti

Dates

2015-07-10—Published

2009-02-06—Filed