FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to a method of micronisation of poorly water-soluble and/or chemically or thermally unstable pharmaceutically active agents, which involves slurrying of the pharmaceutically active agent in gas propellant or compressed gas and high-pressure homogenisation processing of this suspension to produce a dry powder after decompression. Also, the invention concerns an inhalation pharmaceutical composition containing the active agent micronised by the described method and pharmaceutically acceptable excipients. Besides, the invention refers to application of the active agent micronised by the described method in inhalation or parenteral compositions.
EFFECT: method provides producing particles of herd-to-grind micrometre and submicrometre active agents with controlled particle size distribution.
21 cl, 3 dwg, 2 tbl, 5 ex
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