PHARMACEUTICAL COMPOSITION CONTAINING ELEMENE, METHOD FOR ITS PREPARATION AND USE THEREOF Russian patent published in 2025 - IPC A61K31/15 A61K31/337 A61K31/437 A61K31/7068 A61K39/395 A61K47/02 A61K47/04 A61K47/06 A61K47/10 A61K47/12 A61K47/14 A61K47/18 A61K47/26 A61K47/36 A61K47/42 A61K47/44 A61K9/10 A61K9/12 A61K9/14 A61K9/19 A61P35/00 A61P35/02 A61P35/04 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions relates to the field of pharmaceutics, namely to a pharmaceutical composition for preventing or treating cancer, methods of producing said composition, using said composition to produce a drug for preventing or treating cancer, a method of treating cancer, pharmaceutical composition for preventing or treating cancer, a sealed container. Pharmaceutical composition for preventing or treating cancer contains elemene, an oil for injections and a protein carrier, wherein said oil for injections is soya bean oil, said protein carrier is albumin, wherein the weight ratio of soya oil to the elemene is about 0.35 to 3, the weight ratio of albumin to the elemene is about 0.5 to 20. Method of producing said composition includes the following steps: (1) uniform mixing of elemene and oil for injection, addition of organic solvent to obtain solution of elemene and oil for injection; dissolving the protein carrier in water to obtain a protein carrier solution; (2) mixing two solutions obtained in step (1) to obtain an emulsion; (3) homogenizing the emulsion in step (2) under high pressure and evaporating the emulsion under reduced pressure to remove the organic solvent to obtain a nanoparticle solution, where said oil for injection is soya bean oil, said protein carrier is albumin, wherein the weight ratio of soya oil to the elemene is about 0.35 to 3, the weight ratio of albumin to the elemene is about 0.5 to 20. Method of producing said composition includes the following steps: (1) uniform mixing of elemene and oil for injection to obtain solution of elemene and oil for injection; dissolving the protein carrier in water to obtain a protein carrier solution; (2) mixing two solutions obtained in step (1) to obtain an emulsion; (3) homogenisation of the emulsion at step (2) under high pressure to obtain a solution of nanoparticles, where said oil for injections, the protein carrier and their weight ratio to the elemene are characterized as described above. Disclosed is use of said composition for producing a drug for preventing or treating cancer. Method of treating cancer involves administering to a subject in need thereof a therapeutically effective amount of said composition. Pharmaceutical composition for preventing or treating cancer contains said composition. Sealed container contains said composition or said composition.

EFFECT: said group of inventions enables to create an effective and safe composition based on albumin, containing an elemene.

57 cl, 9 dwg, 15 tbl, 31 ex