SUBSTITUTED GAMMA-LACTAMS AS THERAPEUTIC AGENTS Russian patent published in 2011 - IPC C07D207/26 C07D405/12 C07D409/12 A61K31/4015 A61K31/402 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel compounds of formula: or its pharmaceutically acceptable salts, where Y represents COOR²; A represents -(CH₂)₆-, cys-CH₂CH=CH-(CH₂)₃-, where 1 carbon atom can be substituted with O; or A represents -(CH₂)_m-Ar-(CH₂)₀-, where Ar represents phenylene or 5-member heteroarylene, which contains one heteroatom selected from O or S, sum of m and o constitutes from 1 to 4, and where one of groups CH₂ can be substituted with O; and B represents phenyl, which can be substituted with C_1-12 alkyl, hydroxy C_1-12 alkyl; R² represents H, C_1-6 alkyl.

EFFECT: obtaining compounds for ophthalmological composition.

15 cl, 1 tbl, 16 dwg, 43 ex