POLYMORPHOUS FORM OF 4-[3-(4-CYCLOPROPANE CARBONYL PIPERAZINE-1-CARBONYL)-4-FLUOROBENZENE)-2H-PHTHALAZIN-1-ONE Russian patent published in 2012 - IPC C07D237/32 A61K31/502 A61P35/00 

Abstract RU 2465270 C2

FIELD: chemistry.

SUBSTANCE: invention relates to 4-[3-(4-cyclopropane carbonyl piperazine-1-carbonyl)-4-fluorobenzene)-2H-phthalazin-1-one in crystalline form A, as well as methods for production thereof and a pharmaceutical composition for inhibiting PARP based thereon. A novel form of 4-[3-(4-cyclopropane carbonyl piperazine-1-carbonyl)-4-fluorobenzene)-2H-phthalazin-1-one is obtained, which contains fewer impurities and can be used to produce high-purity pharmaceutical drug formulations.

EFFECT: fewer impurities.

12 cl, 5 dwg, 6 ex

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RU 2 465 270 C2

Authors

Meniar Kejt Alan

Otridzh Ehntoni Piter

Londesbrougkh Derek Dzhon

Khalet Majkl Rehjmond

Malkholland Kejt Rehjmond

Pitam Dzhon Dehvid

Laffan Dehvid Dermot Patrik

Ehshvort Jan Vudvord

Dzhons Martin Frehnsis

Cherimehn Dzhenet Khelen

Dates

2012-10-27Published

2007-10-15Filed