FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to organic chemistry and medicine, and concerns an improved method for preparing 4-chlor-N-(2-morpholinoethyl)benzamide being a substance of the drug moclobemide, by reaction of 4-chlorbenzoylchloride with 2-morpholinoethylamine in a water-immiscible solvent medium, wherein a product is dissolved by processing a reaction mixture by aqueous alkaline solutions followed by separation from an organic layer by substituting a first solvent for non-polar one, and filtering.
EFFECT: method allows preparing a high-yield (95% of the theory) product of high compendial grade (100 %, HELC) without crystalline modification.
3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED ACYLAMINOBENZAMIDES HAVING FUNGICIDAL ACTIVITY AND PROCESS FOR PREPARING THEREOF | 1990 |
|
RU2034829C1 |
| TRICYCLIC DIAZEPINE VASOPRESSIN AND OXYTOCIN ANTAGONISTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT | 1994 |
|
RU2126006C1 |
| TRICYCLIC DERIVATIVES, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND METHOD OF INHIBITION OF VASOPRESSINE | 1994 |
|
RU2149160C1 |
| METHOD FOR PRODUCTION OF ACYL AMINOBENZAMIDE DERIVATIVES | 1991 |
|
RU2032662C1 |
| DIPHENYLAMINE DERIVATIVE PRODUCING METHOD | 0 |
|
SU628811A3 |
| METHOD OF OBTAINING GLUCOSAMINE DERIVATIVES OR SALTS THEREOF | 0 |
|
SU660589A3 |
| DERIVATIVES OF TRIAZOLEBENZAZEPINE, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUND FOR THEIR SYNTHESIS, PHARMACEUTICAL ANTIHISTAMINIC COMPOSITION AND METHOD OF ITS PREPARING | 1993 |
|
RU2126802C1 |
| METHOD OF PREPARING DERIVATIVES OF 5(OR 6)-ACYLATED BENZIMIDAZOLCARBOXYLIC-2 ACIDS OR THEIR SALTS | 0 |
|
SU888819A3 |
| TRICYCLIC COMPOUNDS, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION AND TREATMENT METHOD | 1998 |
|
RU2213094C2 |
| 0 |
|
SU525428A3 |
