FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to medicine, in particular to pharmaceutical industry, namely to pharmaceutical composition, possessing anticoagulant and cholesterol-lowering properties, which contains heparin, immobilised on polymeric carrier by irradiation by gamma-rays or flux of accelerated electrons, and buffer mixture, with the following component ratio, wt %: heparin 4.0-5.0 polymeric carrier 8.0-10.0 buffer mixture - the remaining part. As polymeric carrier, applied is polyethylene oxide with molecular weight 400-4000 Da or dextran with molecular weight 20000-60000. As buffer mixture, used is 0.025 M sodium phosphate buffer with pH 7.5-8.2.
EFFECT: invention makes it possible to increase treatment efficiency due to increase of peroral bioavailability and extension of composition application range for treatment of diseases accompanied by phenomena of thrombus-formation due to cholesterol-lowering action in combination with anticoagulant properties.
5 cl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| IMMOBILISED BACILLUS LICHENIFORMIS BACTERIA PRODUCED SUBTILISIN SHOWING THROMBOLYTIC AND ANTICOAGULANT PROPERTIES | 2008 |
|
RU2416643C2 |
| PHARMACEUTICAL COMPOSITION ELICITING THROMBOLYTIC, ANTI-INFLAMMATORY AND CYTOPROTECTIVE PROPERTIES | 2001 |
|
RU2213557C2 |
| ANTIBIOTIC CONJUGATE AND ANTIBACTERIAL MEDICINAL AGENT BASED ON SAID CONJUGATE | 2007 |
|
RU2371447C2 |
| METHOD FOR PREVENTION OF DESULPHATION AND HIGH BIOAVAILABILITY OF BIOLOGICALLY ACTIVE SULPHATED ORAL POLYSACCHARIDES | 2009 |
|
RU2421230C2 |
| METHOD OF MEDICINAL AGENT BIOAVAILABILITY INCREASE | 2006 |
|
RU2328309C1 |
| METHOD FOR IMMOBILIZING AN ENZYME, SUBTILISIN-LIKE PROTEINASE, PRODUCED BY A BACTERIUM STRAIN OF THE GENUS BACILLUS OF THE SPECIES BACILLUS SP_ 7P/3-19, ON THE INSTRUMENT | 2017 |
|
RU2663128C1 |
| PROCESS FOR PREPARING IMMOBILIZED FIBRINOLYSIN | 0 |
|
SU1002356A1 |
| HYDROPHILIC POLYMER COMPOUND POSSESSING ANTICOAGULATION EFFECT | 2010 |
|
RU2539566C2 |
| STABILIZED STREPTOKINASE POSSESSING THROMBOLYTIC ACTIVITY | 0 |
|
SU822551A1 |
| METHOD FOR IMMOBILISING BIOLOGICALLY ACTIVE SUBSTANCE (BAS) ON CARRIER (VERSIONS) AND BAS-CARRIER CONJUGATE PRODUCED BY SUCH METHODS | 2008 |
|
RU2409669C9 |
