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IPC

A61K31/737(2006-01-01)

A61K31/727(2006-01-01)

A61K47/00(2006-01-01)

(21) (22)

Application

2009128554/15, 2009-07-23

(24)

Start date

2009-07-23

(22)

Actual filing date

2009-07-23

(45)

Published

2011-06-20

(72)

Inventor

Bekarev Andrej AleksandrovichArtamonov Andrej VladimirovichVereshchagin Evgenij Ivanovich

(73)

Holder

Ooo F'Jucher Menedzhment" Future Management",

METHOD FOR PREVENTION OF DESULPHATION AND HIGH BIOAVAILABILITY OF BIOLOGICALLY ACTIVE SULPHATED ORAL POLYSACCHARIDES Russian patent published in 2011 - IPC A61K31/737 A61K31/727 A61K47/00

Abstract RU 2421230 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, biology, pharmacology. The method is characterised by the fact that biologically active sulphated polysaccharides (BASP) selected from the group: ungraded heparin, low-molecular heparin and fucoidan are mixed with a block copolymer of polyethylene oxide (PEO) and polyoxypropylene (POP). For effect enhancement, the block copolymer solution before mixed with BASP or the solution containing a BASP polymer is exposed to ionising irradiation.

EFFECT: method prevents desulphation of sulphated polysaccharides in a gastrointestinal tract and provides their oral bioavailability which considerably exceeds the oral bioavailability shown for sulphated polysaccharide (heparin) at an activity unit of introduced heparin.

19 cl, 6 tbl, 6 ex

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RU 2 421 230 C2

Authors

Bekarev Andrej Aleksandrovich

Artamonov Andrej Vladimirovich

Vereshchagin Evgenij Ivanovich

Dates

2011-06-20—Published

2009-07-23—Filed