METHOD OF TREATING RECTAL CANCER Russian patent published in 2011 - IPC A61N5/00 A61N5/02 A61K31/282 A61K31/41 A61K31/7068 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly oncology, and can be applied in treating rectal cancer. A method involves radiation teletherapy, drug therapy (capecitabine, oxaliplatin), local UHF hyperthermia, metronidazole as a part of a composite mixture introduced through rectum, and following surgery. Capecitabine is introduced orally in dose 650 mg/m² during the whole course of radiation therapy every 12 hours, oxaliplatin is administered on the 2nd, 9th, 16th days of treatment intravenously in dose 50 mg/m². Local UHF hyperthermia precedes a radiation session on the 8th, 12th, 15th, 17th days of treatment. Radiation is executed at 4 Gy of single basic dose three times a week every 48 hours for 22 days, 40 Gy of total basic dose. Metronidazole as a part of a polymeric composition is introduced on 12th and 17th days of treatment before UHF hyperthermia sessions with exposition 5 hours. The treatment is carried out with underlying protection of surrounding tissues with gas hypoxic mixture GHM-9.

EFFECT: use of the invention allows reaching tumour regress and executing radical surgery due to a synergic effect of the components and an intensified therapeutic effect ensured by implemented mechanisms of radio- and chemosensibilisation.

2 cl, 2 ex