FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula 
in which R1 and R2 independently denote C1-6alkyl; R4 denotes phenyl, substituted with trifluoromethyl if necessary; X denotes hydrogen or methyl; and Y denotes -C(O)R, where R denotes C1-6alkyl; or Y denotes -P(O)(OR5)2, where R5 denotes hydrogen or C1-6alkyl; or pharmaceutically acceptable salts thereof. Said compounds are prodrugs of adenosine A2B receptor. The invention also relates to a pharmaceutical composition which is an adenosine A2B receptor antagonist based on the compound of formula I.
EFFECT: formula I compounds and the pharmaceutical composition can be used in treating different diseases in mammals, such as gastrointestinal disorders, immunological disorders, allergic disorders, neurological disorders, cardiovascular disorders and diseases associated with cell hyperproliferation.
13 cl, 1 tbl, 15 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PREVENTION AND TREATMENT OF LIVER DISEASE WITH APPLICATION OF RECEPTOR A ANTAGONISTS | 2007 |
|
RU2457842C2 |
| METHOD OF PRODUCING ANTAGONISTS OF ADENOSINE RECEPTORS A AND INTERMEDIATE PRODUCTS | 2004 |
|
RU2374247C2 |
| DERIVATIVES OF XANTHINE AS ANTAGONISTS OF ADENOSINE A RECEPTORS | 2003 |
|
RU2318825C2 |
| METHOD OF PREVENTION AND TREATMENT OF RESPIRATORY WAYS REMODELLING AND PNEUMONIA WITH APPLICATION OF ANTAGONISTS OF ADENOSINE RECEPTORS A | 2005 |
|
RU2391103C2 |
| METHOD OF WOUND HEALING WITH APPLYING ANTAGONISTS OF A ADENOSINE RECEPTOR | 2005 |
|
RU2385322C2 |
| ANTAGONISTS OF ADENOSINE A RECEPTORS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR THEIR PREPARING | 2002 |
|
RU2318824C2 |
| PURINE RIBOSIDES AS ANTI-ARRHYTHMIC AGENTS | 2001 |
|
RU2248208C2 |
| NEW SUBSTITUTED 8-HETEROARYLXANTINES AND BASED PHARMACEUTICAL COMPOSITION | 2004 |
|
RU2357969C2 |
| IMIDE MODULATORS OF PROTEOLYSIS AND METHODS FOR USING THEM | 2015 |
|
RU2738833C2 |
| ADENOSINE A3-RECEPTOR MODULATORS | 1999 |
|
RU2250904C2 |
