METHOD OF PRODUCING ANTAGONISTS OF ADENOSINE RECEPTORS A AND INTERMEDIATE PRODUCTS Russian patent published in 2009 - IPC C07D473/06 C07D403/12 

FIELD: chemistry.

SUBSTANCE: invention relates to an improved method of producing compounds of formula I, which are antagonists of adenosine receptors A_2B, and useful in treating different conditions, including asthma and diarrhoea, as well as intermediate compounds for their production. In formula (I) R¹ and R² are independently optionally substituted alkyl; X is pyrazol-4-yl; Y is a covalent bond or a lower alkylene; and Z is optionally substituted monocyclic aryl or optionally substituted monocyclic heteroaryl. The method involves ring closure of the compounds of formula (3): , in which R¹, R², X, Y and Z are as described above, in the presence of a base. In the method new intermediate compounds are obtained, which makes the method of producing compounds of formula I more cost effective since the primary products used are obtained using simple technology.

EFFECT: design of a simple method of obtaining said compounds.

47 cl, 6 dwg, 30 ex