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(19)

(11)

2 416 596

(13)

(51)

IPC

C07C66/02(2006-01-01)

A61K31/122(2006-01-01)

A61K31/192(2006-01-01)

A61K31/194(2006-01-01)

A61K36/48(2006-01-01)

A61K36/70(2006-01-01)

A61K47/18(2006-01-01)

A61K47/22(2006-01-01)

A61K47/26(2006-01-01)

A61K9/06(2006-01-01)

A61K9/10(2006-01-01)

A61K9/107(2006-01-01)

A61K9/12(2006-01-01)

A61K9/20(2006-01-01)

A61K9/48(2006-01-01)

A61K9/70(2006-01-01)

A61P1/04(2006-01-01)

A61P3/10(2006-01-01)

A61K31/185(2006-01-01)

A61K36/185(2006-01-01)

A61K47/16(2006-01-01)

A61P19/02(2006-01-01)

C07C51/41(2006-01-01)

C07D241/12(2006-01-01)

C07C279/14(2006-01-01)

C07H5/06(2006-01-01)

C07C211/63(2006-01-01)

C07C229/26(2006-01-01)

(21) (22)

Application

2008104343/04, 2006-07-10

(24)

Start date

2006-07-10

(22)

Actual filing date

2006-07-10

(45)

Published

2011-04-20

(72)

Inventor

Tsong Ksiaodong

(73)

Holder

Dzhiangsu Lianchuang Farmatsejtikal Teknolodzhi Ko., Ltd

CHRYSOPHANOL CONJUGATE, SYNTHESIS METHOD THEREOF, USE THEREOF AS MEDICINAL AGENT FOR TREATING DIABETIC NEPHROPATHY, INTESTINAL ADHESION, OSTEOARTHRITIS Russian patent published in 2011 - IPC C07C66/02 A61K31/122 A61K31/192 A61K31/194 A61K36/48 A61K36/70 A61K47/18 A61K47/22 A61K47/26 A61K9/06 A61K9/10 A61K9/107 A61K9/12 A61K9/20 A61K9/48 A61K9/70 A61P1/04 A61P3/10 A61K31/185 A61K36/185 A61K47/16 A61P19/02 C07C51/41 C07D241/12 C07C279/14 C07H5/06 C07C211/63 C07C229/26

Abstract RU 2416596 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a chrysophanol conjugate or its derivative, characterised by general formula (I), in which R1-R8 is a group selected from -H, -OH, -OCH₃, -CH₃, provided that not less than two groups from R1-R8 denote -H or provided that one or two of groups R2, R3, R6 and R7 are a -COOH group, M is a nitrogen organic base selected from a group comprising chitosamin, glucosamin, or a basic amino acid selected from a group comprising arginine, lysine, carnitine, and group M is bonded to the chrysophanol part in the conjugate.

EFFECT: invention relates to use of the conjugate as a medicinal agent for preventing or treating diabetic nephropathy, osteoarthritis, rheumatic or rheumatoid arthritis, intestinal adhesion, intestinal peristalsis restoration, and a medicinal agent based on the conjugate.

8 cl, 4 dwg, 57 ex, 18 tbl

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RU 2 416 596 C2

Authors

Tsong Ksiaodong

Dates

2011-04-20—Published

2006-07-10—Filed