HEPATOTROPIC CONJUGATES OF ANTIVIRAL DRUGS, THEIR CARRIERS, PHARMACEUTICAL COMPOSITIONS CONTAINING ON SAID, METHOD OF CONJUGATE PREPARING Russian patent published in 1999 - IPC

FIELD: medicine, pharmacy. SUBSTANCE: invention relates to a method of preparing hepatotropic conjugates that carry out the delivery of drugs in the liver and a pharmaceutical composition containing these conjugates. Antiviral drugs (for example, ara-AMP, aciclovir and others) are conjugated with a carrier taken among polyamino acids and, in part, with poly-L-lysine or poly-L-ornithine where the most part of amino-groups is not substituted with antiviral drugs but substituted with galactose molecules and these preparations are used for treatment of patients with hepatitis. EFFECT: decreased toxicity, absence of antibody formation after intramuscular administration. 15 cl, 3 tbl