FIELD: medicine.
SUBSTANCE: vaccine strain of B/60/Brisbane/08/83 (H1N1) influenza virus is a reassortant prepared by cross breeding an epidemic B/Brisbane/60/2008 virus and a cold-adapted thermally sensitive B/USSR/60/69 (H2N2) virus being a human-safe attenuation donor. The B/60/Brisbane/08/83 strain replicates actively in growing chicken embryos at optimum temperature 32°C. The strain is characterised by thermal sensitivity and cold adaptation. The reassortant has inherited the genes coding surface virus antigens - hemagglutinin (HA) and neuraminidase (NA) from an epidemic parent virus, and six genes coding internal non-glycosylated proteins from the attenuation donor. The B/60/Brisbane/08/83 strain is areactogenic for adults and children in intranasal introduction. In reactogenecity, the vaccine strain of B/60/Brisbane/08/83 influenza virus meets the requirements specified in the Manufacturer's Monograph 42-0504-4097-04 to vaccine strains for live dry allantoic influenza vaccine for intranasal application.
EFFECT: improved strain characteristics.
4 tbl, 2 ex
| Title | Year | Author | Number |
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