PYRAZOLO[1,5-a]PYRIMIDINES, USED AS PROTEIN KINASE INHIBITORS Russian patent published in 2011 - IPC C07D487/04 A61K31/519 A61P35/00 

FIELD: chemistry.

SUBSTANCE: in formula I' , R denotes -(C=Q)R^2a, CN or Y; Y denotes phenyl, or ; Q denotes O; R^2a denotes phenyl, OR⁵ or N(R⁵)₂; R¹ denotes H; Z denotes a bond; R³ and R⁴ denotes H, halogen, C_1-6alkoxy, N(R⁵)₂ or U_m-V, where m equals 0 or 1; V denotes H, phenyl, 5-6-member heteroaryl containing up to two nitrogen atoms, 5-6-member heterocyclyl containing up to two heteroatoms selected from N or O, or C_1-6aliphatic group; U denotes a C_1-6alkylidene chain, where up to two methylene links of the chain may be substituted with -CO₂-, -C(O)-, -C(O)NH-, -C(O)NR⁵; R⁵ denotes H, C_0-6alkykphenyl or C_1-6aliphatic group, or two R⁵ groups, taken together with an atom to which they are bonded are optionally bonded to form a 5-7-member heterocyclic ring containing 1-2 heteroatoms selected from N, O or S; J^Y is selected from N(R⁹)₂, SR⁹, OR⁹, halogen, CN, COOR⁹, -X-OH, phenyl, -X-phenyl, 5-6-member heteroaryl containing up to two nitrogen atoms, -X-(5-6-member heteroaryl containing up to two nitrogen atoms) or X; X denotes a C_1-12aliphatic group; R⁹ denotes H, C_1-6aliphatic group, phenyl, C_3-6cycloaliphatic group, 4-6-member heterocyclyl containing up to 2 nitrogen atoms. Invention also relates to a pharmaceutical composition and a method of inhibiting Tec or c-Met kinase activity.

EFFECT: high inhibiting activity towards Tec or c-Met kinase.

16 cl, 11 tbl, 20 ex