FIELD: chemistry.
SUBSTANCE: invention describes mutations of the amino acid sequence of the protein of atpE mycobacteria (M. tuberculosis and M. smegmatis), which determine their resistance to DARQ J. Obtained are coding mutant forms of atpE nucleic acids, vectors containing said forms and host cells expressing mutant proteins.
EFFECT: invention discloses use of said host cells in a method of identifying compounds which can be used as antimicrobial agents for mycobacteria strains resistant to existing drugs.
5 cl, 4 dwg, 7 tbl
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| METHOD FOR PREPARING INOSINE AND 5'-INOSINIC ACID BY FERMENTATION METHOD BY USING MICROORGANISMS BELONGING TO GENUS Escherichia | 2003 |
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| METHOD OF OBTAINING L-AMINO ACID WITH APPLICATION OF BACTERIUM OF ENTEROBACTERIACEAE FAMILY, WITH WEAKENED EXPRESSION OF GENES, CODING LYSINE/ARGININE/ORNITHINE TRANSPORTER | 2011 |
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| COMPOSITIONS AND METHODS FOR PLANT PEST CONTROL | 2016 |
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| NOVEL PROMOTER AND USE THEREOF | 2017 |
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